Welcome to the Copenhagen Trial Unit − The CTU

The CTU is a clinical intervention research unit conducting clinical research within all specialties. We offer flexible collaboration and consulting at all stages of clinical research.

The CTU has been involved in the conduct of more than 151 randomised clinical trials in which more than 132,000 participants were randomised. We provide expertise and infrastructure in planning, conduct, analysis, and interpretation of randomised clinical trials, including development of trial methodology and education.

The CTU has been involved in the conduct of more than 500 protocols for systematic reviews, which has materialised in the publication of more than 300 systematic reviews published within and outside The Cochrane Collaboration. The CTU has developed methodology and software for conducting Trial Sequential Analysis (TSA). We provide advice, support, and full collaboration during the protocol and systematic review development. We offer expertise in search strategy design, conduct literature searches for systematic reviews, and offer help with or conduct of meta-analyses.

The CTU hosts the Editorial Team Office of the Cochrane Hepato-Biliary Group (CHBG) – one of the 56 global Collaborative Review Groups within The Cochrane Collaboration – as well as the Danish Clinical Research Infrastructures Network (DCRIN) and the Danish coordinating hub of the Nordic Trial Alliance (NTA).

We offer creative collaboration and consulting from concept, through conduct and to completion.

News

Wichmann S, Barbateskovic M, Liang N, et al. Loop diuretics in adult intensive care patients with fluid overload: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. An Intensive Care. 2022 Jun 13;12(1):52. doi: 10.1186/s13613-022-01024-6. PMID: 35696008 Free PMC article. Review.
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Hansen ML, Hyttel-Sørensen S, Jakobsen JC, et al. Cerebral near-infrared spectroscopy monitoring (NIRS) in children and adults: a systematic review with meta-analysis. European Society for Paediatric Research Special Interest Group ‘NearInfraRed Spectroscopy’ (NIRS). Pediatr Res. 2022 Feb 22. doi: 10.1038/s41390-022-01995-z. Online ahead of print. PMID: 35194162 Free article.
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Riberholt CG, Olsen MH, Milan JB, et al. Major mistakes and errors in the use of Trial Sequential Analysis in systematic reviews or meta-analyses - protocol for a systematic review. Syst Rev. 2022 Jun 4;11(1):114. doi: 10.1186/s13643-022-01987-4. PMID: 35659769 Free PMC article.
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Pereira Ribeiro J, Lunde C, Gluud C, et al. Methylphenidate denied access to the WHO List of Essential Medicines for the second time. BMJ Evid Based Med. BMJ Evid Based Med. Resusc Plus. 2022 Jun 2;10:100258. doi: 10.1016/j.resplu.2022.100258. eCollection 2022 Jun. PMID: 35677835 Free PMC article.
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Faltinsen E, Todorovac A, Staxen Bruun L, et al. Control interventions in randomised trials among people with mental health disorders. Cochrane Database Syst Rev. 2022 Apr 4;4(4):MR000050. doi: 10.1002/14651858.MR000050.pub2. PMID: 35377466 Review.
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Korang SK, von Rohden E, Veroniki AA, et al. Vaccines to prevent COVID-19: A living systematic review with Trial Sequential Analysis and network meta-analysis of randomized clinical trials. PLOS ONE. 2022 Jan 21;17(1):e0260733. doi: 10.1371/journal.pone.0260733. eCollection 2022. PMID: 35061702 Free PMC article.
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Granholm A, Kjær MN, Munch MW, et al. Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia. Intensive Care Med. 2022 May;48(5):580-589. doi: 10.1007/s00134-022-06677-2. Epub 2022 Mar 31. PMID: 35359168 Free PMC article. Clinical Trial.
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Meyhoff TM, Hjortrup PB, Wetterslev J, et al. Restriction of Intravenous Fluid in ICU Patients with Septic Shock. N Engl J Med. 2022 Jun 30;386(26):2459-2470. doi: 10.1056/NEJMoa2202707.
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Pagsberg AK, Uhre C, Uhre V, et al. Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents: protocol for a randomised clinical trial (the TECTO trial). BMC Psychiatry. 2022 Mar 19;22(1):204. doi: 10.1186/s12888-021-03669-2. PMID: 35305587 Free PMC article
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Skrifvars MB, Ameloot K, Grand J, et al. Protocol for an individual patient data meta-analysis on blood pressure targets after cardiac arrest. Acta Anaesthesiol Scand. 2022 May 26. doi: 10.1111/aas.14090.
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Gasbjerg KS, Hägi-Pedersen D, Lunn TH, et al. Effect of dexamethasone as an analgesic adjuvant to multimodal pain treatment after total knee arthroplasty: randomised clinical trial. BMJ. 2022 Jan 4;376:e067325. doi: 10.1136/bmj-2021-067325. PMID: 34983775.
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Holgersson J, Meyer MAS, Dankiewicz J, et al. Hypothermic versus Normothermic Temperature Control after Cardiac Arrest. NEJM Evidence. 2022 june 15; DOI:https://doi.org/10.1056/EVIDoa2200137.
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Krauss SR, Barbateskovic M, Klingenberg SL, et al. Aluminium adjuvants versus placebo or no intervention in vaccine randomised clinical trials: a systematic review with meta-analysis and Trial Sequential Analysis. BMJ Open 2022;12:e058795. doi:10.1136/ bmjopen-2021-058795.
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Skrifvars MB, Jakobsen JC. We must keep our cool regarding the effect of therapeutic hypothermia after in-Hospital cardiac arrest. DOI: Chest. 2022 Aug;162(2):281-282. doi: 10.1016/j.chest.2022.03.007.
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