Welcome to the Copenhagen Trial Unit − The CTU

The CTU is a clinical intervention research unit conducting clinical research within all specialties. We offer flexible collaboration and consulting at all stages of clinical research.

The CTU has been involved in the conduct of more than 162 randomised clinical trials in which more than 135,000 participants were randomised. We provide expertise and infrastructure in planning, conduct, analysis, and interpretation of randomised clinical trials, including development of trial methodology and education.

The CTU has been involved in the conduct of more than 500 protocols for systematic reviews, which has materialised in the publication of more than 300 systematic reviews published within and outside The Cochrane Collaboration. The CTU has developed methodology and software for conducting Trial Sequential Analysis (TSA). We provide advice, support, and full collaboration during the protocol and systematic review development. We offer expertise in search strategy design, conduct literature searches for systematic reviews, and offer help with or conduct of meta-analyses.

The CTU hosts the Editorial Team Office of the Cochrane Hepato-Biliary Group (CHBG) – one of the 56 global Collaborative Review Groups within The Cochrane Collaboration – as well as the Danish Clinical Research Infrastructures Network (DCRIN) and the Danish coordinating hub of the Nordic Trial Alliance (NTA).

Since the establishment in 1995, the CTU has produced an average of 38 publications per year. By August 2024, the CTU had a Web of Science Hirsch index of 103.

We offer creative collaboration and consulting from concept, through conduct and to completion.

News

Kamp CB, Petersen JJ, Faltermeier P, et al. Beneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis. BMJ Ment Health 2024;27:1–14. https://doi.org/10.1136/bmjment-2023-300730
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Barakji J, Korang SK, Feinberg J, et al. Cannabinoids versus placebo for pain: A systematic review with meta-analysis and Trial Sequential Analysis. PLoS ONE 18(1): e0267420. 2023 Jan 30 doi: https://doi.org/10.1371/journal.pone.0267420
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Capion T, Lilja-Cyron A, Juhler M, et al. Prompt closure versus gradual weaning of external ventricular drain for hydrocephalus following aneurysmal subarachnoid haemorrhage: a statistical analysis plan for the DRAIN randomised clinical trial. Trials 25, 479 (2024). https://doi.org/10.1186/s13063-024-08305-4.
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Taccone FS, Dankiewicz J, Cariou A, et al. Hypothermia vs Normothermia in Patients With Cardiac Arrest and Nonshockable Rhythm: A Meta-Analysis . JAMA Neurol. 2024;81(2):126–133. doi:10.1001/jamaneurol.2023.4820.
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Jørgensen CK, Olsen MH, Nielsen N, et al. Centre for Statistical and Methodological Excellence (CESAME): A Consortium Initiative for Improving Methodology in Randomised Clinical Trials. Health Services Insights. 2023;16. doi:10.1177/11786329231166519
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Petersen JJ, Jørgensen CK, Faltermeier P, et al. Drug interventions for prevention of COVID-19 progression to severe disease in outpatients: a systematic review with meta-analyses and trial sequential analyses (The LIVING Project). BMJ Open 2023;13:e064498. doi:10.1136/ bmjopen-2022-064498
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Hansen ML, Pellicer A, Hyttel‑Sørensen S, et al. Cerebral Oximetry Monitoring in Extremely Preterm Infants. N Engl J Med 2023;388:1501-11. DOI: 10.1056/NEJMoa2207554
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Rijal A, Nielsen EE, Adhikari TB, et al. Effects of adding exercise to usual care in patients with either hypertension, type 2 diabetes or cardiovascular disease: a systematic review with meta-analysis and trial sequential analysis. Br J Sports Med 2023;57:930–939 doi:10.1136/bjsports-2022-106002.
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Rasmussen MI, Hansen ML., Pellicer A, et al. Cerebral oximetry monitoring versus usual care for extremely preterm infants: a study protocol for the 2-year follow-up of the SafeBoosC-III randomised clinical trial. Trials 24, 653 (2023). https://doi.org/10.1186/s13063-023-07653-x
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Naing C, Ni H, Aung HH, Htet NH, el al, Gene therapy for people with hepatocellular carcinoma. Cochrane Database of Systematic Reviews 2024, Issue 6. Art. No.: CD013731. DOI: 10.1002/14651858.CD013731.pub2. Accessed 19 August 2024.
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Nørskov AK, Jakobsen JC, Afshari A,et al. Collaboration for Evidence-based Practice and Researchin Anaesthesia (CEPRA): A consortium initiative forperioperative research.Acta Anaesthesiol Scand. 2023;67(6):804‐810. doi:10.1111/aas.1423
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Niemela V, Siddiqui F, Ameloot K, et al.Higher versus lower blood pressure targets after cardiac arrest: Systematic review with individual patient data meta-analysis. 2023 june. DOI:https://doi.org/10.1016/j.resuscitation.2023.109862
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Olsen MH, Hansen ML, Lange T, et al. Detailed statistical analysis plan for a secondary Bayesian analysis of the SafeBoosC-III trial: a multinational, randomised clinical trial assessing treatment guided by cerebral oximetry monitoring versus usual care in extremely preterm infants. Trials 24, 737 (2023). https://doi.org/10.1186/s13063-023-07720-3
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Wichmann S, Lange T, Perner A, et al. Furosemide versus placebo for fluid overload in intensive carepatients—The randomised GODIF trial second version:Statistical analysis plan. Acta Anaesthesiol Scand. 2023;1‐7.doi:10.1111/aas.14320
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